For those who follow the latest research in Alzheimer’s disease, we are all too familiar with amyloid plaques, the troublesome buildup thought to be linked to Alzheimer’s. But is it possible that the buildup is, in fact, helpful?
Neuroscientists Rudolph Tanzi and Robert Moir, from Harvard’s influential teaching hospital, Massachusetts General, are making breakthroughs with their latest findings. They’re suggesting that amyloid-beta is actually a constructive part of our immunity, with the task of protecting the brain from foreign cells; much in the way an oyster develops a pearl, for self-protection. Developing this idea, Moir explains, “Maybe amyloid plaques are a brain pearl, a way for our body to trap and permanently sequester these invading pathogens.”
It is a major shift in thinking. Amyloid-beta transitions from being our enemy to becoming a necessary component of our immune system. The problem lies in an overproduction of the plaques that can then impact healthy brain cells, leading to Alzheimer’s disease.
Although the research took years to accomplish, the results are well worth the time put in. Not only were medical scientists able to validate the virus and bacteria killing ability of amyloids in the laboratory, but identical results were found when tested in animal models. In fact, mice with encephalitis and meningitis infections were safeguarded against the disease when producing amyloids, while those lacking amyloids perished within a small period of time.
Theories are still being researched; the immune system could be attacking healthy cells in the brain, not unlike what happens in other autoimmune disorders. Or, it could be the result of an overreaction to a virus or bacteria that enters the brain. Once the cause is pinpointed, it could potentially allow doctors to halt the process in the early stages and prevent the resulting dementia.
Generations at Home is a leader in providing dementia care for those impacted, as we wait for a research breakthrough that leads to a cure. Whether the need is for short-term respite care to allow family caregivers a break, full-time care day and night, or anything in between, we’re available to make life more comfortable for those with dementia and those who care for them. Call us at 727-940-3414 or contact us online to learn more about our services.
